Doctoral

Thesis title:

'Synthetic Studies in Carbohydrate Molecular Diversity: Development of Anti-parasitic Agents'

Guide/Supervisor:

Dr Rama Pati Tripathi Scientist E-II

Central Drug Research Institute (CSIR)

Lucknow-226001, INDIA

Post Doctoral

Project 1: January 2005-February 2006

Title : “Metodologie Syntetiche per la preparazione di composti a potenziale inetresse tossicologico, in particolare nucleosidi e nucleotidi”

[Synthetic methods for the preparation of the compounds of toxicological interest, in particular nucleosides and nucleotides]

Guide/Supervisor: Prof (Dr) Gloria Cristalli, Deputy Vice Chancellor, University of Camerino, Camerino, (MC) 62032. Italy

Project 2: March 2006-June 2007

Title:“Carattarizzazione analitica di prodotti tipici dell’ Appennino marchegiano e sintesi di molecule caratterizzanti”

[Analytical characterization of the products of the typical of the Marche region and the synthesis of the characterized molecules]

Guide/Supervisor: Prof. (Dr.) Gloria Cristalli, Deputy Vice Chancellor & Prof. (Dr.) Gabriella Marucci, Department of Chemistry, University of Camerino, Camerino, (MC) 62032. Italy

Project 3: July 2007-Till date

Title: “Sintesi e caratterizzazione di nuovi nucleosidi e nucleotidi purinici”

[Synthesis and characterization of new purine nucleosides & nucleotides]

Guide/Supervisor: Prof. (Dr.) Gloria Cristalli, Deputy Vice Chancellor, Department of Chemistry, University of Camerino, Camerino, (MC) 62032. Italy

SYNTHETIC STUDIES IN CARBOHYDRATE MOLECULAR DIVERSITY: DEVELOPMENT OF ANTIPARASITIC AGENTS

THESIS SUBMITTED

TO

Dr. R. M. L., AVADH UNIVERSITY

FAIZABAD

FOR THE DEGREE OF

DOCTOR OF PHILOSOPHY

IN

CHEMISTRY

By

Ram Chandra Mishra

M. Sc. (Chemistry)

MEDICINAL & PROCESS CHEMISTRY DIVISION

CENTRAL DRUG RESEARCH INSTITUTE

(Council of Scientific and Industrial Research)

Lucknow-226001, INDIA

2004

Dragendorff Reagent:

The Dragendorff's Reagent is used for the detection of Nitrogenous compounds, alkaloids, antiarrhythmic drugs and surfactants and is also good detector for Phenols.

There are two kinds for preparations, each procedure says preparation of Solution A and Solution B, both are then mixed to use.

1st Method:

Solution A: 1.7 g basic bismuth nitrate in 100 ml water/acetic acid (4:1).

Solution B: 40.0 g potassium iodide in 100 ml of water.

Mix reagents together as follows: 5 ml A + 5 ml B + 20 ml acetic acid + 70 ml water.

Spray plates, orange spots develop. Spots intensify if sprayed later with HCl, or 50% water-phosphoric acid. Good for phenols.

 

2nd Method:

Solution A: 1.7 g basic bismuth nitrate and 20 g tartaric acid in 80 ml of water. 
Solution B:  16 g potassium iodide in 40 ml of water.

Stock solution: (stable several weaks in a refrigerator): mix equal volumes of solutions A and B

 
Procedure:  Spray with a solution of 10 g tartaric acid, 50 ml water & and 5 ml stock solution.